DNA Structure
|
|||||||||||||||
|
|
|
|
|
|||||||||||
Since this is a molecular genetics course, I want to take a little time to review DNA structure.
You can find most of this material in chapter 6 of your text. If we take a nucleic acid sample and hydrolyse it to its components in acid, |
|||||||||||||||
|
||||||||||||
The first two components, phosphoric acid and the sugars, form the linear backbone of nucleic acid polymers.
The phosphoric acid links adjacent sugars via a phospho-diester linkage. The sugar component of nucleic acids consists of two related sugar moities: beta-D-ribofuranose, found in Ribonucleic acids (RNA),
|
||||||||||||
Notice that the two sugars are identical save for the lack of the 2' OH group on the deoxy-ribofuranose. This simple change is responsible for the differential stability of DNA and RNA in the presence of base. The presence of two OH groups on ribofuranose |
||||||||||||
|
||||||||||||